Prednisolone acetate is commonly used in the treatment of canine diseases, but it is also accompanied by many side effects.

On the physiological level, it is easy to cause endocrine disorders. Long-term use of this drug can inhibit the function of the adrenal cortex in dogs, resulting in a decrease in the secretion of endogenous hormones. Once the drug is abruptly stopped, it is difficult for the body to adapt in time, or the symptoms of adrenal cortex dysfunction, such as lethargy, loss of appetite, and weight loss. At the same time, the drug has a significant impact on sugar metabolism, which can increase blood sugar and increase the risk of diabetes in dogs.

From the perspective of the digestive system, prednisolone acetate can irritate the gastrointestinal tract of dogs. Common side effects are vomiting, diarrhea, and other symptoms, and in severe cases, gastrointestinal ulcers and bleeding. Due to its weakening of the protective mechanism of the gastrointestinal mucosa, gastric acid and pepsin are more likely to damage the gastrointestinal mucosa.

In terms of the immune system, although the drug has an immunosuppressive effect, it can help control immune-related diseases in dogs, but it also reduces the dog's resistance. It makes dogs more susceptible to pathogens such as bacteria, viruses and fungi, which increases the chance of infection, and the disease may become more serious after infection, and the difficulty of treatment will also increase.

In addition, the drug may also affect the musculoskeletal system of dogs. Long-term use or cause muscle atrophy, the dog's limb strength is weakened, and the exercise ability is reduced. At the same time, it affects calcium absorption and bone metabolism, increases the risk of osteoporosis, especially in puppies, or affects the normal development of bones.