On the application of prednisolone acetate after excimer laser in situ keratomileusis
1. INTRODUCTION
Today's ophthalmology, excimer laser in situ keratomileusis (Lasik) has been a common method for correcting refractive errors. Postoperative medication is related to vision recovery and eye health. Among them, the application of prednisolone acetate has attracted much attention, and this is a detailed discussion.
Second, the pharmacological properties of prednisolone acetate
Prednisolone acetate is a glucocorticoid drug. It has anti-inflammatory ability, can reduce the infiltration of inflammatory cells, such as neutrophils, lymphocytes, etc., inhibit the release of inflammatory mediators, such as histamine, leukotrienes, etc., to slow down the inflammatory response after eye surgery. And it can immune regulation, regulate the body's immune response, reduce the possibility of immune rejection, and is beneficial to the stability of the ocular microenvironment.
III. The effect of prednisolone acetate after Lasik
(1) Anti-inflammatory and swelling
After Lasik, the corneal flap and surrounding tissues often have inflammatory reactions, which are manifested as redness, swelling and pain. Prednisolone acetate can quickly reduce this inflammation, subside corneal edema, and restore the corneal tissue structure to normal as soon as possible, laying the foundation for good recovery of vision. As can be seen in clinical observation, the time for corneal edema to subside was significantly shorter in those who used prednisolone acetate on time after surgery than in those who did not use it.
(2) Prevention of complications
There may be complications such as corneal opacity and epithelial implantation after surgery. Prednisolone acetate can prevent the formation of corneal opacity by virtue of its anti-inflammatory and immunomodulatory effects, because it can inhibit the proliferation of fibroblasts and collagen synthesis, and avoid abnormal corneal stromal hyperplasia. At the same time, it also plays a certain role in the prevention of epithelial implantation, stabilizing the fit between the corneal flap and the stromal layer.
IV. Guidelines for the use of prednisolone acetate
(1) Timing of administration
Generally, prednisolone acetate is used immediately or within a short period of time after Lasik surgery to control the inflammatory reaction as soon as possible. In the initial stage, the frequency of administration is high, and over time, the inflammation gradually decreases and the frequency decreases.
(2) The dose
depends on the degree of eye inflammation and individual differences. Usually the starting dose is eye drops every 2-4 hours, and then gradually decreases to 3-4 times a day. The specific follow the doctor's instructions. Do not increase or decrease the dose without authorization, so as not to affect the curative effect or cause adverse reactions.
5. Precautions for the use of prednisolone acetate
(1) IOP monitoring
Long-term or improper use of prednisolone acetate can cause increased intraocular pressure. Therefore, during the medication period, it is necessary to monitor the intraocular pressure regularly. If the intraocular pressure is abnormal, the medication should be adjusted in time or measures to reduce intraocular pressure should be taken.
(2) Risk of infection
Although glucocorticoids are anti-inflammatory, they will reduce the body's resistance and increase the risk of eye infection. Patients should keep their eyes clean and avoid rubbing their eyes when taking medication. If there are signs of eye infection, they should seek medical attention in time.
6. Conclusion
The application of prednisolone acetate after Lasik surgery is of great significance for promoting ocular recovery and preventing complications. However, in clinical use, it is necessary to follow the norms and pay close attention to intraocular pressure and infection, so that patients can obtain benefits and avoid harm, achieve good treatment results, and regain a clear vision.
