Whether acetyl-CoA can be a carbon source for gluconeogenesis
The theory of biochemistry
is related to the theory that acetyl-CoA can be a carbon source for gluconeogenesis. There are many opinions. Now we will study it in detail to understand the rationale.

In the case of gluconeogenesis, the process of transforming non-glycemic substances into glucose or glycogen is also the process. It plays a great role in maintaining constant blood sugar levels and supplying energy to specific tissues. The non-glycemic substances involved include lactic acid, pyruvate, glycogenic amino acids and glycerol.

However, the situation of acetyl-CoA is different. It is metabolized in cells and is mostly supplied by cyclic oxidation of tricarboxylic acids. Although it plays a key role in the metabolic network, it is difficult to directly provide carbon sources for gl

What do you mean? The gluconeogenesis pathway has a specific enzyme system and intermediate products. Starting from the carboxylation branch of pyruvate, pyruvate is catalyzed by pyruvate carboxylase to form oxaloacetic acid, and then converted to phosphoenolpyruvate by phosphoenolpyruvate carboxylkinase, and the purpose of gluconeogenesis is achieved by retrograde glycolysis according to specific steps. This process requires precise regulation of specific enzymes, and acetyl-coenzyme A does not participate in this key step.

Furthermore, after acetyl-coenzyme A enters the tricarboxylic acid cycle, two carbon atoms escape in the form of carbon dioxide, which is difficult to reverse transform back to gluconeogenetic intermediates. From the perspective of energy and material transformation balance, it does not meet the requirements of glu

Although acetyl-CoA is a non-gluconeogenous carbon source under physiological conditions, its metabolism is complex and changeable. Under specific pathological or experimental conditions, there may be related metabolic regulation changes, but it still needs to be further explored.

In summary, under normal physiological conditions, acetyl-CoA is difficult to be a carbon source of gluconeogenesis. This is the basic law of biochemical metabolism. However, scientific research and exploration are endless, or there may be new solutions to be discovered in the future.