Dexamethasone Acetate
Triacetin Series Acetate Series Basic Chemicals Casting Materials Organic Ester Series Composite Carbon Source Liquid
Dexamethasone Acetate
Chemical Name 9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate
Molecular Formula C24H31FO6
Molecular Weight 434.5
Appearance White or almost white, crystalline powder
Solubility Practically insoluble in water, freely soluble in acetone, soluble in ethanol (96%)
Melting Point 200 - 205°C
Pharmacological Class Corticosteroid
Mechanism Of Action Binds to glucocorticoid receptors, modulates gene expression
Therapeutic Uses Anti - inflammatory, immunosuppressive, anti - allergic
Half Life Approximately 36 - 54 hours
Route Of Administration Oral, injectable, topical
FAQ

What are the common side effects of dexamethasone acetate?

Tudexamethasone sodium phosphate is a kind of western medicine. Although it is not in the category of traditional Chinese medicine, it is also used in ancient Chinese words to describe its common auxiliary uses.

Tudexamethasone sodium phosphate has anti-inflammatory ability and can control the body's inflammatory response. All kinds of inflammatory diseases, such as joint inflammation, skin inflammation, etc., can exert its force. Such as joint arthralgia, redness, swelling and heat swelling, this medicine can slow inflammation, reduce the pain of swelling and pain, and make the flexion and extension of the joints gradually improve, just like clearing clouds and fog to see the sky, and the joint stagnation can be passed.

It has the effect of immunosuppression. In immune-related diseases, it can adjust the body's immune function. When the immune is too high, the body attacks, causing all kinds of abnormal diseases, this drug can inhibit the immune overdrive, if the reins of the horse are controlled to keep it on the right track, avoid immune chaos and damage to the viscera.

In addition, it has the ability to resist poison. In case of internal invasion of toxic evil, it causes the body to hot topic, dizziness, etc. This drug can help the body resist poison and reduce the harm of toxic evil. Like building embankments to prevent floods, prevent the spread of toxic evil, keep the viscera safe, make the spirit gradually recover, and the heat subsides.

And it can also be used to resist shock. When the body is in danger of shock, the qi and blood are in chaos, and the yin and yang are about to separate. This medicine can help adjust the state of the body, stabilize the internal environment, and reverse the qi and blood. If it is fixed on the sea god needle, the body will gradually come back to life from the endangered situation.

Then use this medicine with caution. Because of its strong strength, it is not used properly, or it may change differently. It must follow the doctor's advice and take into account its advantages and disadvantages before applying the medicine to achieve the purpose of healing and safety.

What diseases is dexamethasone acetate suitable for?

Dexamethasone sodium phosphate is an adrenal corticosteroid drug. It is widely used and can be applied to a variety of diseases. Here are the ancient words, which are described in detail below.

In inflammatory diseases, such as autoimmune inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, etc., this drug is effective. Dexamethasone sodium phosphate can effectively reduce inflammation by inhibiting the aggregation, adhesion and activation of inflammatory cells, reducing the synthesis and release of inflammatory mediators. For example, in rheumatoid arthritis, it can relieve joint swelling and pain, suppress immune disorders, and improve patients' symptoms and quality of life.

In case of allergic diseases, such as severe drug allergy, anaphylactic shock, etc., dexamethasone sodium phosphate is also indispensable. It can stabilize the cell membranes of mast cells and basophils, prevent the release of allergic mediators, and reduce the permeability of blood vessels, reduce tissue edema and exudation caused by allergies. In case of anaphylactic shock, emergency administration of this drug can help patients turn the corner.

In blood system diseases, such as leukemia, lymphoma, etc., dexamethasone sodium phosphate is often used in chemotherapy regimens. It can induce lymphocyte apoptosis, inhibit the proliferation of tumor cells, and enhance the efficacy of chemotherapy drugs. At the same time, it can relieve the nausea, vomiting and other adverse reactions caused by chemotherapy, and help patients complete the treatment smoothly.

In addition, in some patients with adrenal cortical dysfunction, dexamethasone sodium phosphate can be used as an alternative treatment option. It can supplement the deficiency of corticosteroids in the body and maintain the normal physiological functions of the body.

However, when using this drug, the pros and cons should be carefully weighed, because it may be accompanied by many adverse reactions. Doctors should carefully observe the patient's symptoms and use precise medication to avoid serious harm.

What is the correct use of dexamethasone acetate?

Dexamethasone sodium phosphate is a commonly used drug, and its correct usage is as follows.

When used orally, adults usually use 0.75-3mg at a time, 2-4 times a day. After the disease is relieved, the dose should be gradually reduced, and it must not be stopped suddenly to prevent the disease from recurring. In case of some inflammation in the early stage, you can follow the doctor's advice to increase the dose slightly. When the symptoms are stable, slowly reduce the dose and finally maintain the dose. This can control inflammation and reduce adverse reactions.

If used by injection, the usage varies according to the disease and the purpose of treatment. In emergency rescue, such as severe allergic shock and other conditions, it is often administered intravenously. The dose depends on the specific situation of the patient and is accurately determined by the doctor. It is designed to quickly relieve critical symptoms and stabilize the patient's vital signs. For general inflammation treatment, intramuscular injection is also a commonly used way. It can be determined according to the severity of the disease. The appropriate dose and frequency of medication.

When used externally, it is mostly used for skin inflammation. Take an appropriate amount of ointment and apply it evenly to the affected area, gently rub it to help absorb, several times a day. However, it should be noted that the damaged skin should be used with caution to prevent the spread of irritation and infection.

The dosage of pediatric medication must be determined according to factors such as age, weight and condition. It must be determined after careful weighing by the doctor. It must not be administered at will with reference to During the medication period, the child's reaction should be closely observed, and if there is any abnormality, communicate with the doctor immediately.

All users of this medicine should follow the doctor's advice, and must not increase or decrease the dose or stop the medicine by themselves, so as to ensure the safety and effectiveness of the medication and achieve the best therapeutic effect.

What are the interactions between dexamethasone acetate and other medications?

Dexamethasone sodium phosphate is a glucocorticoid drug, and its interaction with other drugs is quite complicated. It is listed below:
When used in combination with non-steroidal anti-inflammatory drugs, the incidence of gastrointestinal adverse reactions can be increased, because both can cause gastrointestinal mucosal damage. If used together, the damage will be superimposed, such as ulcers, bleeding or more likely to occur. In the past, a doctor used the two drugs to treat the patient together. Soon, the patient felt severe epigastric pain, which was later found to be caused by gastric bleeding.
When used in combination with potassium excretion diuretics, the risk of hypokalemia will increase. Gein excreting potassium diuretics can promote the excretion of potassium ions from the body, while dexamethasone also has the effect of excreting potassium, and the synergy between the two intensifies the loss of potassium ions. I once saw a patient with edema. The doctor treated the disease with potassium excreting diuretics and dexamethasone without closely monitoring the blood potassium. After a few days, the patient showed fatigue and palpitations. Blood potassium was measured, and it was found that the value was very low.
Combined with digitalis drugs, hypokalemia is prone to digitalis poisoning. When the edge is low in potassium, the sensitivity of the myocardium to digitalis is greatly increased, and if you are not careful, you will be easily poisoned. If you have an old man, suffer from heart disease, take digitalis drugs, and add dexamethasone due to other diseases, you will soon experience nausea, vomiting, and arrhythmia, which is a symptom of digitalis poisoning.
When used with vaccines, it can cause suppressed immune response. Vaccines are designed to stimulate the body's immune response to fight disease, while dexamethasone has the function of immunosuppression. When used together, the effectiveness of vaccines may be greatly reduced. For example, when children are vaccinated, if this drug is misused, the immune protection expected by the vaccine may be difficult to achieve.
When used with hypoglycemic drugs, it can antagonize the hypoglycemic effect of hypoglycemic drugs. Dexamethasone can raise blood sugar, which is contrary to the effect of hypoglycemic drugs, making it more difficult to regulate blood sugar. There have been diabetic patients who have added dexamethasone on their own, without adjusting the dose of hypoglycemic drugs, blood sugar will rise immediately, and the disease will fluctuate.

When taking all these drugs, it is necessary to carefully review the interaction between drugs and handle them with caution to ensure safety.

What are the precautions for dexamethasone acetate?

Dexamethasone sodium phosphate is a commonly used drug. When using it, many matters must be paid attention to.

The first step is to differentiate the syndrome and apply the medicine. It is necessary to verify the patient's disease syndrome, which is indeed applicable to the category of this drug, before it can be used. If the syndrome is improper, misuse may cause many abnormal syndromes. If the patient has a heat image, but it is virtual heat, not a real heat syndrome, if dexamethasone sodium phosphate is used indiscriminately, not only will it not cure the disease, but it will be easy to kill the righteous qi, making the weak even more weak.

Furthermore, the dosage of this drug must be explained when using it. The dosage should be accurately weighed according to factors such as the patient's age, constitution, and the severity of the disease. Children's viscera are delicate, qi and blood are not full, and the dosage should be light; the elderly's constitution is gradually declining, and heavy doses should not be used. If the dose is too large, it is easy to cause adverse reactions, such as Cushing's syndrome, full moon face, buffalo back, and cardiac obesity; or it may cause blood sugar to rise, blood pressure fluctuations, etc.

The course of medication must also be carefully controlled. Do not abuse for a long time, so as to avoid the body's dependence on drugs, and it is easy to cause the body's immune function to be suppressed. Generally speaking, short-term appropriate application, while the disease is cured, if the disease needs long-term medication, when gradually reducing the dose, slowly stopping the drug, and must not stop suddenly to prevent the disease from rebounding.

During the medication period, it is still necessary to pay close attention to the patient's reaction. Observe whether it has allergic symptoms, such as skin rash, itching, and even shortness of breath; observe its mental state, whether there is irritability, insomnia and other abnormalities. If you see adverse reactions, stop the drug in time and take corresponding treatment measures.

In addition, when used in combination with other drugs, you should be especially cautious. Dexamethasone sodium phosphate is used in combination with certain drugs, which may increase its toxic and side effects or reduce its efficacy. If used in combination with salicylate, it may increase the risk of gastrointestinal ulcers and bleeding; when used in combination with potassium excretion diuretics, it is easy to cause hypokalemia. Therefore, before using the drug, be sure to carefully review the drug used to avoid it.