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What is the scope of application of chlorhexidine acetate?
Chlorhexidine acetate is suitable for antibacterial and disinfection scenarios in many fields: in medicine, it can be used for pre-operative skin disinfection, wound washing, oral gargle (such as gingivitis treatment) and medical device soaking; in the daily chemical industry, it is added to hand sanitizers, shower gels, skin care products, etc. to play an antibacterial and cleaning role; in the industrial field, it is used as a preservative in coatings, glues, etc. to prevent microbial contamination; in animal husbandry, it can be used to disinfect livestock and poultry houses and utensils; in addition, it can also be explored for use in scenarios such as fruit and vegetable preservation. With its broad-spectrum antibacterial properties, it has application value in environments where microbial reproduction needs to be controlled.
What are the side effects of chlorhexidine acetate?
The side effects of chlorhexidine acetate mainly manifest as local irritation and allergic reactions, such as burning sensation, itching, erythema or rash after contact with the skin and mucous membranes, and corneal damage after eye contact; long-term oral use can easily cause tooth staining, taste changes and oral flora imbalance; high-concentration oral administration may cause gastrointestinal discomfort such as nausea, vomiting, abdominal pain, and even central nervous system depression; in addition, long-term and large-scale use may also cause ecotoxicity to aquatic organisms, and there is a potential risk of microbial resistance. Safety should be carefully evaluated when used by special populations (such as pregnant women and children).
How to Use Chlorhexidine Acetate Correctly?
The correct use of chlorhexidine acetate requires the selection of appropriate dosage forms and concentrations according to different scenarios: in medical disinfection, 0.5% - 2% solution (often in combination with ethanol) is commonly used for surgical skin disinfection, 0.05% - 0.1% solution is used for wound washing, and 0.02% - 0.1% solution is used for oral gargle and long-term use should be avoided to prevent tooth staining; formula standards must be followed in daily chemical products, and the concentration of topical preparations such as hand sanitizers is usually less than 0.3%; 0.1% - 0.5% solution should be used for instrument immersion disinfection and attention should be paid to the action time; avoid contact with sensitive areas such as eyes during use. If accidental contact occurs, rinse immediately with clean water; special populations (such as pregnant women and children) should use it under the guidance of a doctor, and be alert to allergic reactions. If any discomfort is found, stop using it and seek medical attention in time. At the same time, avoid using it in combination with soap, anionic surfactants, etc. to prevent reduced efficacy.
Does chlorhexidine acetate interact with other drugs?
Chlorhexidine acetate may interact with a variety of drugs. Because it is a cationic surfactant, its efficacy will be reduced due to charge neutralization when used with soap or anionic surfactants (such as sodium dodecyl sulfate). Redox reactions may occur when used with strong oxidants such as iodine preparations and potassium permanganate, weakening the antibacterial activity. When used in combination with certain cationic drugs (such as benzalkonium bromide), it may compete for the action sites and affect the antibacterial effect. When used in combination with sulfonamides and alkaloids, precipitation or adsorption may occur, reducing drug solubility and bioavailability. In addition, when mixed with alcohol-containing preparations, it may increase skin and mucous membrane irritation. When using it, it is necessary to avoid random compatibility with the above-mentioned drugs. If combination use is necessary, professional medical staff should be consulted to ensure medication safety and efficacy.
What is the preservation method of chlorhexidine acetate?
The storage of chlorhexidine acetate should follow the principles of avoiding light, sealing, and keeping it in a cool and dry place. It should usually be stored at room temperature (10-30℃) and avoid direct sunlight and high temperature and humidity to prevent drug degradation or deterioration; its aqueous solution or preparation should be sealed and stored in the original container to prevent volatilization or contamination, and special attention should be paid to avoid contact with metal containers to avoid chemical reactions that affect stability; alcohol-containing compound preparations should be kept away from fire sources to prevent the risk of combustion and explosion; different dosage forms (such as solutions, suppositories, ointments, etc.) should be stored according to the storage conditions marked on the instructions. It is prohibited to use them when they are expired or have changes in properties (such as discoloration, turbidity, precipitation) to ensure the quality and safety of the drug.